| First Author | Perl AK | Year | 1999 |
| Journal | Nat Med | Volume | 5 |
| Issue | 3 | Pages | 286-91 |
| PubMed ID | 10086383 | Mgi Jnum | J:53305 |
| Mgi Id | MGI:1332278 | Doi | 10.1038/6502 |
| Citation | Perl AK, et al. (1999) Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells. Nat Med 5(3):286-91 |
| abstractText | As in the development of many human cancers, in a transgenic mouse model of beta-cell carcinogenesis (Rip1Tag2), expression of neural cell adhesion molecule (NCAM) changes from the 120-kDa isoform in normal tissue to the 140/180-kDa isoforms in tumors. NCAM-deficient RiplTag2 mice, generated by crossing Rip1Tag2 mice with NCAM knockout mice, develop metastases, a tumor stage that is not seen in normal Rip1Tag2 mice. In contrast, overexpression of NCAM 120 in NCAM-deficient Rip1Tag2 mice prevents tumor metastasis. The results indicate that the loss of NCAM-mediated cell adhesion is one rate-limiting step in the actual metastatic dissemination of beta tumor cells. |
