| First Author | Gugasyan R | Year | 2012 |
| Journal | EMBO J | Volume | 31 |
| Issue | 3 | Pages | 692-706 |
| PubMed ID | 22124325 | Mgi Jnum | J:181776 |
| Mgi Id | MGI:5314168 | Doi | 10.1038/emboj.2011.435 |
| Citation | Gugasyan R, et al. (2012) The NF-kappaB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties. EMBO J 31(3):692-706 |
| abstractText | The role of specific members of the NF-kappaB family of transcription factors in CD8 T-cell selection and development is largely unknown. Here, we show that mice lacking NF-kappaB1 develop a unique population of conventional CD8 single-positive (SP) thymocytes with memory T cell-like properties that populate peripheral immune organs. Development of this memory-like population is not due to PLZF(+) thymocytes and instead coincides with changes in CD8 T-cell selection. These include a reduction in the efficiency of negative selection and a dependence on MHC class Ia or Ib expressed by haematopoietic cells. These findings indicate that NF-kappaB1 regulates multiple events in the thymus that collectively inhibit the excess development of CD8(+) thymocytes with memory cell characteristics. |
