| First Author | Murray SS | Year | 1999 |
| Journal | Neurosci Lett | Volume | 267 |
| Issue | 1 | Pages | 45-8 |
| PubMed ID | 10400245 | Mgi Jnum | J:107967 |
| Mgi Id | MGI:3622602 | Doi | 10.1016/s0304-3940(99)00330-4 |
| Citation | Murray SS, et al. (1999) Differential loss of spinal sensory but not motor neurons in the p75NTR knockout mouse. Neurosci Lett 267(1):45-8 |
| abstractText | Sensory neurons in the dorsal root ganglia (DRG) and motor neurons in the spinal cord express the 75 kDa low-affinity neurotrophin receptor (p75NTR) during prenatal development. The p75NTR gene knockout mouse provides a unique opportunity to assess the role of p75NTR during this period. Quantitative analysis of the p75NTR knockout mouse revealed a significant developmental loss of sensory neurons. In the cervico-thoracic ganglia approximately 75% of the neurons are lost, while in the lumbar ganglia the loss is approximately 50%. In contrast, motor neurons were not lost in either the cervical or lumbar spinal cord. These data suggest that p75NTR is essential for the prenatal survival of a significant number of sensory, but not motor neurons. |
