| First Author | Schachtrup C | Year | 2015 |
| Journal | Nat Neurosci | Volume | 18 |
| Issue | 8 | Pages | 1077-80 |
| PubMed ID | 26120963 | Mgi Jnum | J:225716 |
| Mgi Id | MGI:5694270 | Doi | 10.1038/nn.4054 |
| Citation | Schachtrup C, et al. (2015) Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-beta signaling and astrocyte functions. Nat Neurosci 18(8):1077-80 |
| abstractText | Astrocytes modulate neuronal activity and inhibit regeneration. We show that cleaved p75 neurotrophin receptor (p75(NTR)) is a component of the nuclear pore complex (NPC) required for glial scar formation and reduced gamma oscillations in mice via regulation of transforming growth factor (TGF)-beta signaling. Cleaved p75(NTR) interacts with nucleoporins to promote Smad2 nucleocytoplasmic shuttling. Thus, NPC remodeling by regulated intramembrane cleavage of p75(NTR) controls astrocyte-neuronal communication in response to profibrotic factors. |
