| First Author | Xu R | Year | 2013 |
| Journal | Neuron | Volume | 78 |
| Issue | 4 | Pages | 623-30 |
| PubMed ID | 23719162 | Mgi Jnum | J:201545 |
| Mgi Id | MGI:5514313 | Doi | 10.1016/j.neuron.2013.03.021 |
| Citation | Xu R, et al. (2013) Behavioral effects of cocaine mediated by nitric oxide-GAPDH transcriptional signaling. Neuron 78(4):623-30 |
| abstractText | Cocaine's behavioral-stimulant effects derive from potentiation of synaptic signaling by dopamine and serotonin leading to transcriptional alterations in postsynaptic cells. We report that a signaling cascade involving nitric oxide (NO) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mediates cocaine's transcriptional and behavioral actions. Lower, behavioral-stimulant doses enhance the cAMP response element-binding (CREB) signaling system, while higher, neurotoxic doses stimulate the p53 cytotoxic system. The drug CGP3466B, which potently and selectively blocks GAPDH nitrosylation and GAPDH-Siah binding, prevents these actions as well as behavioral effects of cocaine providing a strategy for anticocaine therapy. |
