| First Author | Liberatore GT | Year | 1999 |
| Journal | Nat Med | Volume | 5 |
| Issue | 12 | Pages | 1403-9 |
| PubMed ID | 10581083 | Mgi Jnum | J:58724 |
| Mgi Id | MGI:1349525 | Doi | 10.1038/70978 |
| Citation | Liberatore GT, et al. (1999) Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease [see comments]. Nat Med 5(12):1403-9 |
| abstractText | MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) damages dopaminergic neurons as seen in Parkinson disease. Here we show that after administration of MPTP to mice, there was a robust gliosis in the substantia nigra pars compacta associated with significant upregulation of inducible nitric oxide synthase (iNOS). These changes preceded or paralleled MPTP-induced dopaminergic neurodegeneration. We also show that mutant mice lacking the iNOS gene were significantly more resistant to MPTP than their wild-type littermates. This study demonstrates that iNOS is important in the MPTP neurotoxic process and indicates that inhibitors of iNOS may provide protective benefit in the treatment of Parkinson disease. |
