| First Author | Isaksson J | Year | 2005 |
| Journal | Spinal Cord | Volume | 43 |
| Issue | 3 | Pages | 167-70 |
| PubMed ID | 15520837 | Mgi Jnum | J:110081 |
| Mgi Id | MGI:3639073 | Doi | 10.1038/sj.sc.3101672 |
| Citation | Isaksson J, et al. (2005) Improved functional outcome after spinal cord injury in iNOS-deficient mice. Spinal Cord 43(3):167-70 |
| abstractText | STUDY DESIGN: Functional outcome was evaluated following experimental compression-type spinal cord injury (SCI) in wild-type mice and knockout mice, lacking the inducible nitric oxide synthase (iNOS) gene. OBJECTIVES: To evaluate the role of the nitric oxide generating enzyme iNOS in SCI. METHODS: The experimental animals were subjected to an extradural compression of the thoracic spinal cord. Functional outcome was studied during the first 2 weeks post-injury using a scoring system for assessment of hind limb motor function. RESULTS: Injury resulted in initial paraplegia followed by gradual improvement of motor function in most cases. Mice lacking the iNOS gene (iNOS-/-) clearly tended to have a better functional outcome than wild-type mice. The difference was significant on day 14 after injury. CONCLUSION: In accordance with a few earlier experimental studies, showing beneficial effects of pharmacological iNOS inhibition, the present report would indicate a destructive influence of iNOS following spinal cord trauma. |
