| First Author | van Elsas MJ | Year | 2024 |
| Journal | Cancer Cell | Volume | 42 |
| Issue | 6 | Pages | 1032-1050.e10 |
| PubMed ID | 38759656 | Mgi Jnum | J:349430 |
| Mgi Id | MGI:7646765 | Doi | 10.1016/j.ccell.2024.04.011 |
| Citation | van Elsas MJ, et al. (2024) Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy. Cancer Cell |
| abstractText | Total tumor clearance through immunotherapy is associated with a fully coordinated innate and adaptive immune response, but knowledge on the exact contribution of each immune cell subset is limited. We show that therapy-induced intratumoral CD8(+) T cells recruited and skewed late-stage activated M1-like macrophages, which were critical for effective tumor control in two different murine models of cancer immunotherapy. The activated CD8(+) T cells summon these macrophages into the tumor and their close vicinity via CCR5 signaling. Exposure of non-polarized macrophages to activated T cell supernatant and tumor lysate recapitulates the late-stage activated and tumoricidal phenotype in vitro. The transcriptomic signature of these macrophages is also detected in a similar macrophage population present in human tumors and coincides with clinical response to immune checkpoint inhibitors. The requirement of a functional co-operation between CD8(+) T cells and effector macrophages for effective immunotherapy gives warning to combinations with broad macrophage-targeting strategies. |
