| First Author | Nishikawa M | Year | 2004 |
| Journal | Carcinogenesis | Volume | 25 |
| Issue | 11 | Pages | 2101-5 |
| PubMed ID | 15205363 | Mgi Jnum | J:93780 |
| Mgi Id | MGI:3505676 | Doi | 10.1093/carcin/bgh218 |
| Citation | Nishikawa M, et al. (2004) Inducible NO synthase inhibits the growth of free tumor cells, but enhances the growth of solid tumors. Carcinogenesis 25(11):2101-5 |
| abstractText | To elucidate the role of nitric oxide (NO) in tumor cell growth in vivo, dynamic aspects of the growth of Ehrlich ascites tumor cells (EATCs) were studied in wild-type (WT) mice and in an inducible strain of NO synthase (iNOS)-deficient (iNOS(-/-)) mice. Kinetic analysis showed that the rate of free tumor cell growth in the peritoneal cavity was significantly higher in the iNOS(-/-) mice than in the WT mice. In contrast, EATCs inoculated subcutaneously rapidly grew and formed a solid tumor in WT mice, but failed to grow in iNOS(-/-) mice. These results clearly indicate that NO generated by iNOS predominantly inhibits the growth of tumor cells in their free form, but enhances the growth of solid tumors. |
