| First Author | Barcia Durán JG | Year | 2021 |
| Journal | Commun Biol | Volume | 4 |
| Issue | 1 | Pages | 406 |
| PubMed ID | 33767339 | Mgi Jnum | J:342695 |
| Mgi Id | MGI:6714996 | Doi | 10.1038/s42003-021-01846-3 |
| Citation | Barcia Duran JG, et al. (2021) Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice. Commun Biol 4(1):406 |
| abstractText | Jak3 is the only non-promiscuous member of the Jak family of secondary messengers. Studies to date have focused on understanding and targeting the cell-autonomous role of Jak3 in immunity, while functional Jak3 expression outside the hematopoietic system remains largely unreported. We show that Jak3 is expressed in endothelial cells across hematopoietic and non-hematopoietic organs, with heightened expression in the bone marrow. The bone marrow niche is understood as a network of different cell types that regulate hematopoietic function. We show that the Jak3(-/-) bone marrow niche is deleterious for the maintenance of long-term repopulating hematopoietic stem cells (LT-HSCs) and that JAK3-overexpressing endothelial cells have increased potential to expand LT-HSCs in vitro. This work may serve to identify a novel function for a highly specific tyrosine kinase in the bone marrow vascular niche and to further characterize the LT-HSC function of sinusoidal endothelium. |
