| First Author | Gordon JA | Year | 1996 |
| Journal | Neuron | Volume | 17 |
| Issue | 3 | Pages | 491-9 |
| PubMed ID | 8816712 | Mgi Jnum | J:35373 |
| Mgi Id | MGI:82822 | Doi | 10.1016/s0896-6273(00)80181-6 |
| Citation | Gordon JA, et al. (1996) Deficient plasticity in the primary visual cortex of alpha-calcium/calmodulin-dependent protein kinase II mutant mice. Neuron 17(3):491-9 |
| abstractText | The recent characterization of plasticity in the mouse visual cortex permits the use of mutant mice to investigate the cellular mechanisms underlying activity-dependent development. As calcium-dependent signaling pathways have been implicated in neuronal plasticity, we examined visual cortical plasticity in mice lacking the alpha-isoform of calcium/calmodulin-dependent protein kinase II (alpha CaMKII). In wild-type mice, brief occlusion of vision in one eye during a critical period reduces responses in the visual cortex. In half of the alpha CaMKII-deficient mice, visual cortical responses developed normally, but visual cortical plasticity was greatly diminished. After intensive training, spatial learning in the Morris water maze was severely impaired in a similar fraction of mutant animals. These data indicate that loss of alpha CaMKII results in a severe but variable defect in neuronal plasticity. |
