| First Author | Landis MW | Year | 2006 |
| Journal | Cancer Cell | Volume | 9 |
| Issue | 1 | Pages | 13-22 |
| PubMed ID | 16413468 | Mgi Jnum | J:105045 |
| Mgi Id | MGI:3613336 | Doi | 10.1016/j.ccr.2005.12.019 |
| Citation | Landis MW, et al. (2006) Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell 9(1):13-22 |
| abstractText | Cyclin D1 is a multifunctional protein that activates CDK4 and CDK6, titrates Cip/Kip CDK inhibitors to increase CDK2 activity, and modulates the function of certain transcription factors. To specifically test the importance of cyclin D1-associated kinase activity, we generated 'knockin' mice expressing mutant cyclin D1 deficient in activating CDK4/6. The development of several cyclin D1-dependent compartments, including mammary glands, proceeds relatively normally in these animals, demonstrating that cyclin D1-associated kinase activity is largely dispensable for development of these tissues. Strikingly, knockin mice were resistant to breast cancers initiated by ErbB-2. These results demonstrate a differential requirement for cyclin D1-CDK4/6 kinase activity in development versus tumorigenesis and strongly support cyclin D1-dependent kinase activity as a specific therapeutic target in breast cancer. |
