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Publication : Granulocytic ehrlichiosis in mice deficient in phagocyte oxidase or inducible nitric oxide synthase.

First Author  Banerjee R Year  2000
Journal  Infect Immun Volume  68
Issue  7 Pages  4361-2
PubMed ID  10858261 Mgi Jnum  J:90886
Mgi Id  MGI:3045211 Doi  10.1128/iai.68.7.4361-4362.2000
Citation  Banerjee R, et al. (2000) Granulocytic ehrlichiosis in mice deficient in phagocyte oxidase or inducible nitric oxide synthase. Infect Immun 68(7):4361-2
abstractText  Mice deficient in phox (gp91(phox-/-)) or NOS2 (NOS2(-/-)) were infected with the agent of human granulocytic ehrlichiosis (HGE) to evaluate the importance of these pathways in the eradication of HGE bacteria. NOS2(-/-) mice had delayed clearance of the HGE agent in comparison to control or gp91(phox-/-) mice, suggesting that reactive nitrogen intermediates play a role in the early control of HGE.
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