| First Author | Roy A | Year | 2000 |
| Journal | Brain Res | Volume | 872 |
| Issue | 1-2 | Pages | 188-93 |
| PubMed ID | 10924691 | Mgi Jnum | J:63733 |
| Mgi Id | MGI:1861521 | Doi | 10.1016/s0006-8993(00)02458-6 |
| Citation | Roy A, et al. (2000) Mice lacking in gp91 phox subunit of NAD(P)H oxidase showed glomus cell [Ca(2+)](i) and respiratory responses to hypoxia. Brain Res 872(1-2):188-93 |
| abstractText | The hypothesis that NAD(P)H oxidase may serve as an oxygen sensor was tested using the mice deficient (knock-out) in gp91phox subunit of NAD(P)H oxidase enzyme complex and compared with wild-type (C57BL/6J) strain measuring the ventilatory and glomus cell intracellular calcium ([Ca(2+)](i)) responses of carotid body to hypoxia. The hypoxic ventilatory responses as well as the [Ca(2+)](i) were preserved in the NAD(P)H oxidase knock-out mice. NAD(P)H oxidase, though a major source of oxygen radical production, is not the oxygen sensor in mice carotid body. |
