| First Author | Cenci E | Year | 1998 |
| Journal | J Immunol | Volume | 161 |
| Issue | 7 | Pages | 3543-50 |
| PubMed ID | 9759875 | Mgi Jnum | J:115201 |
| Mgi Id | MGI:3690837 | Doi | 10.4049/jimmunol.161.7.3543 |
| Citation | Cenci E, et al. (1998) IFN-gamma is required for IL-12 responsiveness in mice with Candida albicans infection. J Immunol 161(7):3543-50 |
| abstractText | To elucidate the role of IFN-gamma in antifungal CD4+ Th-dependent immunity, 129/Sv/Ev mice deficient for IFN-gamma receptor (IFN-gammaR(-/-)) were assessed for susceptibility to gastrointestinal or systemic Candida albicans infection and for parameters of innate and adaptive T helper immunity. IFN-gammaR(-/-) mice failed to mount protective Th1-mediated acquired immunity upon mucosal immunization or in response to a live vaccine strain of the yeast. The impaired Th1-mediated resistance correlated with defective IL-12 responsiveness, but not IL-12 production, and occurred in the presence of an increased innate antifungal resistance. The development of nonprotective Th2 responses was observed in IFN-gammaR(-/-) mice upon mucosal infection and subsequent reinfection. However, under experimental conditions of Th2 cell activation, the occurrence of Th2 cell responses was similar in IFN-gammaR(-/-) and in IFN-gammaR(+/+) mice. These results indicate the complex immunoregulatory role of IFN-gamma in the induction of mucosal and nonmucosal anticandidal Th cell responses; IFN-gamma is not essential for the occurrence of Th2 responses but is required for development of IL-12-dependent protective Th1-dependent immunity. |
