| First Author | Gu X | Year | 2013 |
| Journal | Clin Dev Immunol | Volume | 2013 |
| Pages | 389807 | PubMed ID | 23737812 |
| Mgi Jnum | J:337162 | Mgi Id | MGI:6839576 |
| Doi | 10.1155/2013/389807 | Citation | Gu X, et al. (2013) Interferon- gamma triggers hepatic stellate cell-mediated immune regulation through MEK/ERK signaling pathway. Clin Dev Immunol 2013:389807 |
| abstractText | Hepatic stellate cells (HSCs) interact with immune cells to actively participate in regulating immune response in the liver which is mediated by the effector molecules, including B7-H1. We demonstrated here that expression of B7-H1 on HSCs was markedly enhanced by interferon-(IFN-) gamma stimulation. IFN- gamma stimulated HSCs inhibited T-cell proliferation via induction of T-cell apoptosis (22.1% +/- 1.6%). This immunosuppressive effect was inhibited by preincubation with an anti-B7-H1 antibody, or inhibitor of the MEK/ERK pathway inhibited IFN- gamma mediated expression of B7-H1. Thus, regulation of B7-H1 expression on HSCs by IFN- gamma represents an important mechanism that regulates immune responses in the liver favoring tolerogenicity rather than immunogenicity. Involvement of MEK/ERK pathway provides a novel target for therapeutic approaches. |
