| First Author | Carmeliet P | Year | 1994 |
| Journal | Nature | Volume | 368 |
| Issue | 6470 | Pages | 419-24 |
| PubMed ID | 8133887 | Mgi Jnum | J:17427 |
| Mgi Id | MGI:65465 | Doi | 10.1038/368419a0 |
| Citation | Carmeliet P, et al. (1994) Physiological consequences of loss of plasminogen activator gene function in mice. Nature 368(6470):419-24 |
| abstractText | Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator, in many proteolytic processes. Inactivation of the t-PA gene impairs clot lysis and inactivation of the u-PA gene results in occasional fibrin deposition. Mice with combined t-PA and u-PA deficiency suffer extensive spontaneous fibrin deposition, with its associated effects on growth, fertility and survival. |
