| First Author | Miyazaki I | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 25 | Pages | 5003-8 |
| PubMed ID | 17910954 | Mgi Jnum | J:126937 |
| Mgi Id | MGI:3762324 | Doi | 10.1016/j.febslet.2007.09.046 |
| Citation | Miyazaki I, et al. (2007) Protective effects of metallothionein against dopamine quinone-induced dopaminergic neurotoxicity. FEBS Lett 581(25):5003-8 |
| abstractText | Dopamine (DA) quinone as DA neuron-specific oxidative stress conjugates with cysteine residues in functional proteins to form quinoproteins. Here, we examined the effects of cysteine-rich metal-binding proteins, metallothionein (MT)-1 and -2, on DA quinone-induced neurotoxicity. MT quenched DA semiquinones in vitro. In dopaminergic cells, DA exposure increased quinoproteins and decreased cell viability; these were ameliorated by pretreatment with MT-inducer zinc. Repeated L-DOPA administration markedly elevated striatal quinoprotein levels and reduced the DA nerve terminals specifically on the lesioned side in MT-knockout parkinsonian mice, but not in wild-type mice. Our results suggested that intrinsic MT protects against L-DOPA-induced DA quinone neurotoxicity in parkinsonian mice by its quinone-quenching property. |
