| First Author | Carrasco J | Year | 2003 |
| Journal | Neurobiol Dis | Volume | 13 |
| Issue | 1 | Pages | 22-36 |
| PubMed ID | 12758064 | Mgi Jnum | J:126845 |
| Mgi Id | MGI:3762093 | Doi | 10.1016/s0969-9961(03)00015-9 |
| Citation | Carrasco J, et al. (2003) Role of metallothionein-III following central nervous system damage. Neurobiol Dis 13(1):22-36 |
| abstractText | We evaluated the physiological relevance of metallothionein-III (MT-III) in the central nervous system following damage caused by a focal cryolesion onto the cortex by studying Mt3-null mice. In normal mice, dramatic astrogliosis and microgliosis and T-cell infiltration were observed in the area surrounding the lesioned tissue, along with signs of increased oxidative stress and apoptosis. There was also significant upregulation of cytokines/growth factors such as tumor necrosis factor-alpha, interleukin (IL)-1 alpha/beta, and IL-6 as measured by ribonuclease protection assay. Mt3-null mice did not differ from control mice in these responses, in sharp contrast to results obtained in Mt1- Mt2-null mice. In contrast, Mt3-null mice showed increased expression of several neurotrophins as well as of the neuronal sprouting factor GAP-43. Thus, unlike MT-I and MT-II, MT-III does not affect the inflammatory response elicited in the central nervous system by a cryoinjury, nor does it serve an important antioxidant role, but it may influence neuronal regeneration during the recovery process. |
