| First Author | Gonzalez CD | Year | 1992 |
| Journal | Teratology | Volume | 46 |
| Issue | 6 | Pages | 605-13 |
| PubMed ID | 1290161 | Mgi Jnum | J:3469 |
| Mgi Id | MGI:51982 | Doi | 10.1002/tera.1420460610 |
| Citation | Gonzalez CD, et al. (1992) Craniometric measurements of craniofacial malformations in the X-linked hypophosphatemic (Hyp) mouse on two different genetic backgrounds: C57BL/6J and B6C3H. Teratology 46(6):605-13 |
| abstractText | This study reports data on craniometric measurements in the X-linked hypophosphatemic (Hyp) mouse on two different genetic backgrounds: C57BL/6J and B6C3H. Heads of normal females +/+, normal males +/Y, heterozygous mutant females Hyp/+, and hemizygous mutant males Hyp/Y for each genetic background were examined. Data were collected via skull measurements. On a C57BL/6J background, the neurocranium of mutants Hyp/+ and Hyp/Y was shorter and slightly higher than in normal counterparts. On a B6C3H background, mutant mice Hyp/+ and Hyp/Y were shorter in neurocranial length than in normal counterparts. Viscerocranial height was larger in Hyp/Y than in normal counterparts. No differences in neurocranial and mandibular height were found. Mutant mice on a C57BL/6J background were compared to mutant mice on a B6C3H background. No differences in neurocranial length were found. Cranial length was shorter in Hyp/Y on C57BL/6J than in Hyp/+ on B6C3H. Facial length parameters were shorter in Hyp/Y on C57BL/6J than in Hyp/Y and Hyp/+ mutant mice on B6C3H. Mandibular length was shorter in Hyp/Y on C57BL/6J than in Hyp/+ on C57BL/6J and both mutant mice (Hyp/Y and Hyp/+) on a B6C3H background. The results of this study indicate that craniofacial growth is less affected in mutant mice on a B6C3H genetic background than in mutant mice on a C57BL/6J genetic background. |
