| First Author | Podlasek CA | Year | 1999 |
| Journal | J Urol | Volume | 161 |
| Issue | 5 | Pages | 1655-61 |
| PubMed ID | 10210434 | Mgi Jnum | J:54823 |
| Mgi Id | MGI:1336094 | Citation | Podlasek CA, et al. (1999) Hoxa-13 gene mutation results in abnormal seminal vesicle and prostate development. J Urol 161(5):1655-61 |
| abstractText | The role of Hoxa-13 in postnatal morphogenesis of the male accessory sex organs was assessed by correlating the Hoxa- 13 expression domain with phenotypic abnormalities in heterozygous Hypodactyly mutants. Hypodactyly is a naturally occurring semi-dominant mutation that results from a 50-base pair deletion in exon one of the Hoxa-13 allele. We demonstrate that Hoxa-13 is broadly expressed in the developing lower genitourinary tract and that the Hypodactyly mutation results in a specific phenotype characterized by decreased size and branching of the dorsolateral and ventral prostate and abnormal seminal vesicle morphology. This phenotype partially overlaps the genitourinary phenotype observed in Hoxd-13 deficient mice and comparison showed similar domains of Hoxa-13 and Hoxd- 13 expression in the lower genitourinary tract. The similarity in expression and overlap in phenotype resulting from mutation is consistent with additive function and partial functional redundancy of Hoxa-13 and Hoxd-13 in male accessory sex organ development. |
