| First Author | Finn-Sell SL | Year | 2016 |
| Journal | Placenta | Volume | 42 |
| Pages | 25-7 | PubMed ID | 27238710 |
| Mgi Jnum | J:327449 | Mgi Id | MGI:6884179 |
| Doi | 10.1016/j.placenta.2016.04.003 | Citation | Finn-Sell SL, et al. (2016) The atrial natriuretic peptide (ANP) knockout mouse does not exhibit the phenotypic features of pre-eclampsia or demonstrate fetal growth restriction. Placenta 42:25-7 |
| abstractText | The ANP knockout mouse is reported to exhibit pregnancy-associated hypertension, proteinuria and impaired placental trophoblast invasion and spiral artery remodeling, key features of pre-eclampsia (PE). We hypothesized that these mice may provide a relevant model of human PE with associated fetal growth restriction (FGR). Here, we investigated pregnancies of ANP wild type (ANP(+/+)), heterozygous (ANP(+/-)) and knockout (ANP(-/-)) mice. Maternal blood pressure did not differ between genotypes (E12.5, E17.5), and fetal weight (E18.5) was unaffected. Placental weight was greater in ANP(-/-) versus ANP(+/+) mice. Therefore, in our hands, the ANP model does not express phenotypic features of PE with FGR. |
