| First Author | Smith DJ | Year | 2003 |
| Journal | Neurosci Lett | Volume | 340 |
| Issue | 2 | Pages | 103-6 |
| PubMed ID | 12668247 | Mgi Jnum | J:107939 |
| Mgi Id | MGI:3622574 | Doi | 10.1016/s0304-3940(03)00084-3 |
| Citation | Smith DJ, et al. (2003) Neurotrophin-4 is required for tolerance to morphine in the mouse. Neurosci Lett 340(2):103-6 |
| abstractText | Tolerance is an important component of opiate addiction, but the molecular basis for this phenomenon remains obscure. Here, we report that mice lacking neurotrophin-4 (NT4) display substantially reduced tolerance to morphine compared to wild-type. However, there were no deficits in sensitization and withdrawal, other behaviors relevant to drug addiction. Since NT4 knockout mice also show abnormalities in long-term but not short-term memory, our findings suggest common molecular pathways for some of the enduring changes of drug addiction and memory consolidation. |
