| First Author | Zlotnikov-Klionsky Y | Year | 2015 |
| Journal | Immunity | Volume | 43 |
| Issue | 4 | Pages | 776-87 |
| PubMed ID | 26384546 | Mgi Jnum | J:233784 |
| Mgi Id | MGI:5788057 | Doi | 10.1016/j.immuni.2015.08.015 |
| Citation | Zlotnikov-Klionsky Y, et al. (2015) Perforin-Positive Dendritic Cells Exhibit an Immuno-regulatory Role in Metabolic Syndrome and Autoimmunity. Immunity 43(4):776-87 |
| abstractText | Emerging evidence suggests that immunological mechanisms underlie metabolic control of adipose tissue. Here, we have shown the regulatory impact of a rare subpopulation of dendritic cells, rich in perforin-containing granules (perf-DCs). Using bone marrow transplantation to generate animals selectively lacking perf-DCs, we found that these chimeras progressively gained weight and exhibited features of metabolic syndrome. This phenotype was associated with an altered repertoire of T cells residing in adipose tissue and could be completely prevented by T cell depletion in vivo. A similar impact of perf-DCs on inflammatory T cells was also found in a well-defined model of multiple sclerosis, experimental autoimmune encephlalomyelitis (EAE). Thus, perf-DCs probably represent a regulatory cell subpopulation critical for protection from metabolic syndrome and autoimmunity. |
