| First Author | Ohsawa M | Year | 2001 |
| Journal | Eur J Pharmacol | Volume | 429 |
| Issue | 1-3 | Pages | 157-60 |
| PubMed ID | 11698038 | Mgi Jnum | J:102599 |
| Mgi Id | MGI:3607821 | Doi | 10.1016/s0014-2999(01)01317-6 |
| Citation | Ohsawa M, et al. (2001) Reduced hyperalgesia induced by nerve injury, but not by inflammation in mice lacking protein kinase C gamma isoform. Eur J Pharmacol 429(1-3):157-60 |
| abstractText | Protein kinase C is one of protein kinases which might be involved in the nerve injury- or inflammation-induced hyperalgesia. The present study was designed to investigate the hyperalgesia with thermal paw-withdrawal test induced by sciatic nerve ligation or by intraplantar injection of a complete Freund's adjuvant solution in protein kinase C gamma knockout and its wild-type mice. Either sciatic nerve ligation or intraplantar injection of a complete Freund's adjuvant caused a marked decrease of the paw-withdrawal latency only on the ipsilateral, but not on the contralateral side of the paw in wild-type mice. This ipsilateral hyperalgesia induced by sciatic nerve ligation was significantly attenuated in protein kinase C gamma knockout mice. On the other hand, the ipsilateral hyperalgesia induced by complete Freund's adjuvant remained about the same in protein kinase C gamma knockout mice as in wild-type mice. The results indicate that protein kinase C gamma is involved in the development of the thermal hyperalgesia induced by nerve ligation, but not by complete Freund's adjuvant-induced inflammation. |
