| First Author | Bednarek E | Year | 2011 |
| Journal | Neuron | Volume | 69 |
| Issue | 6 | Pages | 1132-46 |
| PubMed ID | 21435558 | Mgi Jnum | J:174730 |
| Mgi Id | MGI:5140673 | Doi | 10.1016/j.neuron.2011.02.034 |
| Citation | Bednarek E, et al. (2011) beta-Adducin is required for stable assembly of new synapses and improved memory upon environmental enrichment. Neuron 69(6):1132-46 |
| abstractText | Learning is correlated with the assembly of new synapses, but the roles of synaptogenesis processes in memory are poorly understood. Here, we show that mice lacking beta-Adducin fail to assemble new synapses upon enhanced plasticity and exhibit diminished long-term hippocampal memory upon environmental enrichment. Enrichment-enhanced the disassembly and assembly of dynamic subpopulations of synapses. Upon enrichment, stable assembly of new synapses depended on the presence of beta-Adducin, disassembly involved beta-Adducin phosphorylation through PKC, and both were required for augmented learning. In the absence of beta-Adducin, enrichment still led to an increase in spine structures, but the assembly of synapses at those spines was compromised. Virus-mediated re-expression of beta-Adducin in hippocampal granule cells of beta-Adducin(-/-) mice rescued new synapse assembly and learning upon enrichment. Our results provide evidence that synapse disassembly and the establishment of new synapses are both critically important for augmented long-term learning and memory upon environmental enrichment. |
