| First Author | Powell CM | Year | 2004 |
| Journal | Neuron | Volume | 42 |
| Issue | 1 | Pages | 143-53 |
| PubMed ID | 15066271 | Mgi Jnum | J:89753 |
| Mgi Id | MGI:3041363 | Doi | 10.1016/s0896-6273(04)00146-1 |
| Citation | Powell CM, et al. (2004) The presynaptic active zone protein RIM1alpha is critical for normal learning and memory. Neuron 42(1):143-53 |
| abstractText | The active zone protein RIM1alpha is required both for maintaining normal probability of neurotransmitter release and for long-term presynaptic potentiation at brain synapses. We now demonstrate that RIM1alpha(-/-) mice exhibit normal coordination and anxiety-related behaviors but display severely impaired learning and memory. Mice with a synaptotagmin 1 mutation, which selectively lowers release probability, and mice with Rab3A deletion, which selectively abolishes presynaptic long-term potentiation, do not exhibit this abnormality. Our data suggest that a decrease in release probability or a loss of presynaptic LTP alone is not sufficient to cause major behavioral alterations, but the combination of presynaptic abnormalities in RIM1alpha(-/-) mice severely alters learning and memory. |
