| First Author | Lokwani R | Year | 2024 |
| Journal | Nat Mater | Volume | 23 |
| Issue | 1 | Pages | 147-157 |
| PubMed ID | 37872423 | Mgi Jnum | J:358284 |
| Mgi Id | MGI:7778519 | Doi | 10.1038/s41563-023-01689-9 |
| Citation | Lokwani R, et al. (2024) Pro-regenerative biomaterials recruit immunoregulatory dendritic cells after traumatic injury. Nat Mater 23(1):147-157 |
| abstractText | During wound healing and surgical implantation, the body establishes a delicate balance between immune activation to fight off infection and clear debris and immune tolerance to control reactivity against self-tissue. Nonetheless, how such a balance is achieved is not well understood. Here we describe that pro-regenerative biomaterials for muscle injury treatment promote the proliferation of a BATF3-dependent CD103(+)XCR1(+)CD206(+)CD301b(+) dendritic cell population associated with cross-presentation and self-tolerance. Upregulation of E-cadherin, the ligand for CD103, and XCL-1 in injured tissue suggests a mechanism for cell recruitment to trauma. Muscle injury recruited natural killer cells that produced Xcl1 when stimulated with fragmented extracellular matrix. Without cross-presenting cells, T-cell activation increases, pro-regenerative macrophage polarization decreases and there are alterations in myogenesis, adipogenesis, fibrosis and increased muscle calcification. These results, previously observed in cancer progression, suggest a fundamental mechanism of immune regulation in trauma and material implantation with implications for both short- and long-term injury recovery. |
