| First Author | Kim PJ | Year | 2006 |
| Journal | J Immunol | Volume | 177 |
| Issue | 10 | Pages | 6650-9 |
| PubMed ID | 17082577 | Mgi Jnum | J:140498 |
| Mgi Id | MGI:3813999 | Doi | 10.4049/jimmunol.177.10.6650 |
| Citation | Kim PJ, et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J Immunol 177(10):6650-9 |
| abstractText | Although invariant NKT (iNKT) cells participate in many aspects of immune responses, the molecular mechanisms regulating their development, maturation, and activation are still poorly understood. GATA-3 is a T cell-specific transcription factor that is also expressed in iNKT cells. The critical role of GATA-3 in conventional alphabeta T cells has been well documented, but whether GATA-3 also regulates the development and function of iNKT cells is unknown. In the present study, we report that deficiency of GATA-3 results in cell-intrinsic defects in the thymic development and peripheral maturation of murine iNKT cells. In addition, GATA-3 is also required for survival, activation, and effector functions of this unique population of T cells. Our data also reveal a previously unidentified peripheral maturation step that is GATA-3 dependent. |
