| First Author | De Kluyver RL | Year | 2010 |
| Journal | J Invest Dermatol | Volume | 130 |
| Issue | 7 | Pages | 1841-8 |
| PubMed ID | 20237491 | Mgi Jnum | J:161011 |
| Mgi Id | MGI:4456934 | Doi | 10.1038/jid.2010.49 |
| Citation | De Kluyver RL, et al. (2010) Antigen-specific CD8 T cells can eliminate antigen-bearing keratinocytes with clonogenic potential via an IFN-gamma-dependent mechanism. J Invest Dermatol 130(7):1841-8 |
| abstractText | The immune system surveys the skin for keratinocytes (KCs) infected by viruses or with acquired genetic damage. The mechanism by which T cells mediate KC elimination is however undefined. In this study we show that antigen-specific CD8 T cells can eliminate antigen-bearing KCs in vivo and inhibit their clonogenic potential in vitro, independently of the effector molecules perforin and Fas-ligand (Fas-L). In contrast, IFN-gamma receptor expression on KCs and T cells producing IFN-gamma are each necessary and sufficient for in vitro inhibition of KC clonogenic potential. Thus, antigen-specific cytotoxic T lymphocytes (CTLs) may mediate destruction of epithelium expressing non-self antigen by eliminating KCs with potential for self-renewal through an IFN-gamma-dependent mechanism. |
