| First Author | Hiltensperger M | Year | 2021 |
| Journal | Nat Immunol | Volume | 22 |
| Issue | 7 | Pages | 880-892 |
| PubMed ID | 34099917 | Mgi Jnum | J:354562 |
| Mgi Id | MGI:6740256 | Doi | 10.1038/s41590-021-00948-8 |
| Citation | Hiltensperger M, et al. (2021) Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity. Nat Immunol 22(7):880-892 |
| abstractText | Multidimensional single-cell analyses of T cells have fueled the debate about whether there is extensive plasticity or 'mixed' priming of helper T cell subsets in vivo. Here, we developed an experimental framework to probe the idea that the site of priming in the systemic immune compartment is a determinant of helper T cell-induced immunopathology in remote organs. By site-specific in vivo labeling of antigen-specific T cells in inguinal (i) or gut draining mesenteric (m) lymph nodes, we show that i-T cells and m-T cells isolated from the inflamed central nervous system (CNS) in a model of multiple sclerosis (MS) are distinct. i-T cells were Cxcr6(+), and m-T cells expressed P2rx7. Notably, m-T cells infiltrated white matter, while i-T cells were also recruited to gray matter. Therefore, we propose that the definition of helper T cell subsets by their site of priming may guide an advanced understanding of helper T cell biology in health and disease. |
