| First Author | Withers DR | Year | 2012 |
| Journal | J Immunol | Volume | 189 |
| Issue | 5 | Pages | 2094-8 |
| PubMed ID | 22855716 | Mgi Jnum | J:189848 |
| Mgi Id | MGI:5447122 | Doi | 10.4049/jimmunol.1201639 |
| Citation | Withers DR, et al. (2012) Cutting edge: lymphoid tissue inducer cells maintain memory CD4 T cells within secondary lymphoid tissue. J Immunol 189(5):2094-8 |
| abstractText | Phylogeny shows that CD4 T cell memory and lymph nodes coevolved in placental mammals. In ontogeny, retinoic acid orphan receptor (ROR)gamma-dependent lymphoid tissue inducer (LTi) cells program the development of mammalian lymph nodes. In this study, we show that although primary CD4 T cell expansion is normal in RORgamma-deficient mice, the persistence of memory CD4 T cells is RORgamma-dependent. Furthermore, using bone marrow chimeric mice we demonstrate that LTi cells are the key RORgamma-expressing cell type sufficient for memory CD4 T cell survival in the absence of persistent Ag. This effect was specific for CD4 T cells, as memory CD8 T cells survived equally well in the presence or absence of LTi cells. These data demonstrate a novel role for LTi cells, archetypal members of the innate lymphoid cell family, in supporting memory CD4 T cell survival in vivo. |
