| First Author | Zeng Q | Year | 2022 |
| Journal | iScience | Volume | 25 |
| Issue | 10 | Pages | 105151 |
| PubMed ID | 36185364 | Mgi Jnum | J:330543 |
| Mgi Id | MGI:7345170 | Doi | 10.1016/j.isci.2022.105151 |
| Citation | Zeng Q, et al. (2022) Cbl-b restrains priming of pathogenic Th17 cells via the inhibition of IL-6 production by macrophages. iScience 25(10):105151 |
| abstractText | E3 ubiquitin ligase Cbl-b is involved in the maintenance of a balance between immunity and tolerance. Mice lacking Cbl-b are highly susceptible to experimental autoimmune encephalomyelitis (EAE), a Th17-mediated autoimmune disease. However, how Cbl-b regulates Th17 cell responses remains unclear. In this study, utilizing adoptive transfer and cell type-specific Cblb knockout strains, we show that Cbl-b expression in macrophages, but not T cells or dendritic cells (DCs), restrains the generation of pathogenic Th17 cells and the development of EAE. Cbl-b inhibits IL-6 production by macrophages that is induced by signaling from CARD9-dependent C-type lectin receptor (CLR) pathways, which directs T cells to generate pathogenic Th17 cells. Therefore, our data unveil a previously unappreciated function for Cbl-b in the regulation of pathogenic Th17 responses. |
