| First Author | Yao S | Year | 2009 |
| Journal | Blood | Volume | 113 |
| Issue | 23 | Pages | 5811-8 |
| PubMed ID | 19339692 | Mgi Jnum | J:149357 |
| Mgi Id | MGI:3848368 | Doi | 10.1182/blood-2009-02-203141 |
| Citation | Yao S, et al. (2009) PD-1 on dendritic cells impedes innate immunity against bacterial infection. Blood 113(23):5811-8 |
| abstractText | Programmed death one (PD-1) is an inducible molecule belonging to the immunoglobulin superfamily. It is expressed on activated T and B lymphocytes and plays pivotal roles in the negative regulation of adaptive immune responses. We report here an unexpected finding: that PD-1 could also be induced on splenic dendritic cells (DCs) by various inflammatory stimuli. Adoptive transfer of PD-1-deficient DCs demonstrates their superior capacity to wild-type DCs in innate protection of mice against lethal infection by Listeria monocytogenes. Furthermore, PD-1-deficient mice are also more resistant to the infection than wild-type controls, even in the absence of T and B cells, accompanied by elevated production of DC-derived interleukin-12 and tumor necrosis factor-alpha. Our results reveal a novel role of PD-1 in the negative regulation of DC function during innate immune response. |
