| First Author | Akama-Garren EH | Year | 2024 |
| Journal | Sci Immunol | Volume | 9 |
| Issue | 92 | Pages | eadj7029 |
| PubMed ID | 38363829 | Mgi Jnum | J:354962 |
| Mgi Id | MGI:7736810 | Doi | 10.1126/sciimmunol.adj7029 |
| Citation | Akama-Garren EH, et al. (2024) T cell help shapes B cell tolerance. Sci Immunol 9(92):eadj7029 |
| abstractText | T cell help is a crucial component of the normal humoral immune response, yet whether it promotes or restrains autoreactive B cell responses remains unclear. Here, we observe that autoreactive germinal centers require T cell help for their formation and persistence. Using retrogenic chimeras transduced with candidate TCRs, we demonstrate that a follicular T cell repertoire restricted to a single autoreactive TCR, but not a foreign antigen-specific TCR, is sufficient to initiate autoreactive germinal centers. Follicular T cell specificity influences the breadth of epitope spreading by regulating wild-type B cell entry into autoreactive germinal centers. These results demonstrate that TCR-dependent T cell help can promote loss of B cell tolerance and that epitope spreading is determined by TCR specificity. |
