| First Author | El Andaloussi A | Year | 2006 |
| Journal | Nat Immunol | Volume | 7 |
| Issue | 4 | Pages | 418-26 |
| PubMed ID | 16518394 | Mgi Jnum | J:112555 |
| Mgi Id | MGI:3662776 | Doi | 10.1038/ni1313 |
| Citation | El Andaloussi A, et al. (2006) Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nat Immunol 7(4):418-26 |
| abstractText | Commitment of hematopoietic progenitors to the T cell lineage requires the integration of multiple signaling pathways. Evidence has suggested involvement of hedgehog (Hh) signaling in T cell differentiation through its signal transducer smoothened (Smo). However, the precise function of the Hh pathway remains controversial, mainly because T cell-specific in vivo genetic models have not been used. Using pre-T cell-specific, mature T cell-specific and poly(I).poly(C)-inducible deletions of Smo and antagonists of Smo signaling, we report here that Hh is an essential positive regulator of T cell progenitor differentiation. Furthermore, we localize Hh function to a stage preceding pre-T cell receptor signaling, connect Smo signaling to the activity of the Gli1 and Gli2 transcription factors and demonstrate that Hh affects regulators of thymocyte survival and proliferation. |
