| First Author | Gutcher I | Year | 2011 |
| Journal | Immunity | Volume | 34 |
| Issue | 3 | Pages | 396-408 |
| PubMed ID | 21435587 | Mgi Jnum | J:169839 |
| Mgi Id | MGI:4943342 | Doi | 10.1016/j.immuni.2011.03.005 |
| Citation | Gutcher I, et al. (2011) Autocrine Transforming Growth Factor-beta1 Promotes In Vivo Th17 Cell Differentiation. Immunity 34(3):396-408 |
| abstractText | TGF-beta1 is a regulatory cytokine that has an important role in controlling T cell differentiation. T cell-produced TGF-beta1 acts on T cells to promote Th17 cell differentiation and the development of experimental autoimmune encephalomyelitis (EAE). However, the exact TGF-beta1-producing T cell subset required for Th17 cell generation and its cellular mechanism of action remain unknown. Here we showed that deletion of the Tgfb1 gene from activated T cells and Treg cells, but not Treg cells alone, abrogated Th17 cell differentiation, resulting in almost complete protection from EAE. Furthermore, differentiation of T cells both in vitro and in vivo demonstrated that TGF-beta1 was highly expressed by Th17 cells and acted in a predominantly autocrine manner to maintain Th17 cells in vivo. These findings reveal an essential role for activated T cell-produced TGF-beta1 in promoting the differentiation of Th17 cells and controlling inflammatory diseases. |
