| First Author | Zhang P | Year | 2013 |
| Journal | Blood | Volume | 122 |
| Issue | 13 | Pages | 2224-32 |
| PubMed ID | 23940283 | Mgi Jnum | J:202490 |
| Mgi Id | MGI:5519179 | Doi | 10.1182/blood-2013-05-503250 |
| Citation | Zhang P, et al. (2013) PARP-1 regulates expression of TGF-beta receptors in T cells. Blood 122(13):2224-32 |
| abstractText | Transforming growth factor-beta (TGF-beta) receptors (TbetaRs) are essential components for TGF-beta signal transduction in T cells, yet the mechanisms by which the receptors are regulated remain poorly understood. We show here that Poly(ADP-ribose) polymerase-1 (PARP-1) regulates TGF-beta receptor I (TbetaRI) and II (TbetaRII) expression in CD4(+) T cells and subsequently affects Smad2/3-mediated TGF-beta signal transduction. Inhibition of PARP-1 led to the upregulation of both TbetaRI and TbetaRII, yet the underlying molecular mechanisms were distinct. PARP-1 selectively bound to the promoter of TbetaRII, whereas the enzymatic activity of PARP-1 was responsible for the inhibition of TbetaRI expression. Importantly, inhibition of PARP-1 also enhanced expression of TbetaRs in human CD4(+) T cells. Thus, PARP-1 regulates TbetaR expression and TGF-beta signaling in T cells. |
