| First Author | Igyarto BZ | Year | 2009 |
| Journal | J Immunol | Volume | 183 |
| Issue | 8 | Pages | 5085-93 |
| PubMed ID | 19801524 | Mgi Jnum | J:153580 |
| Mgi Id | MGI:4365833 | Doi | 10.4049/jimmunol.0901884 |
| Citation | Igyarto BZ, et al. (2009) Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10. J Immunol 183(8):5085-93 |
| abstractText | Mice lacking epidermal Langerhans cells (LC) develop exaggerated contact-hypersensitivity (CHS) responses due to the absence of LC during sensitization/initiation. Examination of T cell responses reveals that the absence of LC leads to increased numbers of hapten-specific CD4 and CD8 T cells but does not alter cytokine expression or development of T regulatory cells. CHS responses and Ag-specific T cells are increased in mice in which MHC class II is ablated specifically in LC suggesting that direct cognate interaction between LC and CD4 cells is required for suppression. LC-derived IL-10 is also required for optimal inhibition of CHS. Both LC-derived IL-10-mediated suppression and full LC activation require LC expression of MHC class II. These data support a model in which cognate interaction of LC with CD4 T cells enables LC to inhibit expansion of Ag-specific responses via elaboration of IL-10. |
