| First Author | Kedia S | Year | 2024 |
| Journal | Nat Neurosci | Volume | 27 |
| Issue | 8 | Pages | 1468-1474 |
| PubMed ID | 38937583 | Mgi Jnum | J:359459 |
| Mgi Id | MGI:7787167 | Doi | 10.1038/s41593-024-01682-8 |
| Citation | Kedia S, et al. (2024) T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis. Nat Neurosci 27(8):1468-1474 |
| abstractText | Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer's disease remains uncertain, despite age being a major risk factor. Using a mouse model of Alzheimer's disease, we found that amyloidosis itself triggers age-related oligodendrocyte and myelin damage. Mechanistically, CD8(+) T cells promote the progressive accumulation of abnormally interferon-activated microglia that display myelin-damaging activity. Thus, our data suggest that immune responses against myelinating oligodendrocytes may contribute to neurodegenerative diseases with amyloidosis. |
