| First Author | Oh H | Year | 2017 |
| Journal | Immunity | Volume | 47 |
| Issue | 3 | Pages | 450-465.e5 |
| PubMed ID | 28889947 | Mgi Jnum | J:259027 |
| Mgi Id | MGI:6142516 | Doi | 10.1016/j.immuni.2017.08.010 |
| Citation | Oh H, et al. (2017) An NF-kappaB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function. Immunity 47(3):450-465.e5 |
| abstractText | Both conventional T (Tconv) cells and regulatory T (Treg) cells are activated through ligation of the T cell receptor (TCR) complex, leading to the induction of the transcription factor NF-kappaB. In Tconv cells, NF-kappaB regulates expression of genes essential for T cell activation, proliferation, and function. However the role of NF-kappaB in Treg function remains unclear. We conditionally deleted canonical NF-kappaB members p65 and c-Rel in developing and mature Treg cells and found they have unique but partially redundant roles. c-Rel was critical for thymic Treg development while p65 was essential for mature Treg identity and maintenance of immune tolerance. Transcriptome and NF-kappaB p65 binding analyses demonstrated a lineage specific, NF-kappaB-dependent transcriptional program, enabled by enhanced chromatin accessibility. These dual roles of canonical NF-kappaB in Tconv and Treg cells highlight the functional plasticity of the NF-kappaB signaling pathway and underscores the need for more selective strategies to therapeutically target NF-kappaB. |
