| First Author | Koka R | Year | 2004 |
| Journal | J Immunol | Volume | 173 |
| Issue | 6 | Pages | 3594-8 |
| PubMed ID | 15356102 | Mgi Jnum | J:92759 |
| Mgi Id | MGI:3054478 | Doi | 10.4049/jimmunol.173.6.3594 |
| Citation | Koka R, et al. (2004) Cutting edge: murine dendritic cells require IL-15Ralpha to prime NK cells. J Immunol 173(6):3594-8 |
| abstractText | NK cells protect hosts against viral pathogens and transformed cells, and dendritic cells (DCs) play important roles in activating NK cells. We now find that murine IL-15Ralpha-deficient DCs fail to support NK cell cytolytic activity and elaboration of IFN-gamma, despite the fact that these DCs express normal levels of costimulatory molecules and IL-12. By contrast, IL-15Ralpha expression on NK cells is entirely dispensable for their activation by DCs. In addition, blockade with anti-IL-15Ralpha and anti-IL-2Rbeta but not anti-IL-2Ralpha-specific Abs prevents NK cell activation by wild-type DCs. Finally, presentation of IL-15 by purified IL-15Ralpha/Fc in trans synergizes with IL-12 to support NK cell priming. These findings suggest that murine DCs require IL-15Ralpha to present IL-15 in trans to NK cells during NK cell priming. |
