| First Author | Kishikawa S | Year | 2017 |
| Journal | Nat Commun | Volume | 8 |
| Pages | 14509 | PubMed ID | 28224999 |
| Mgi Jnum | J:244829 | Mgi Id | MGI:5913608 |
| Doi | 10.1038/ncomms14509 | Citation | Kishikawa S, et al. (2017) Allograft inflammatory factor 1 is a regulator of transcytosis in M cells. Nat Commun 8:14509 |
| abstractText | M cells in follicle-associated epithelium (FAE) are specialized antigen-sampling cells that take up intestinal luminal antigens. Transcription factor Spi-B regulates M-cell maturation, but the molecules that promote transcytosis within M cells are not fully identified. Here we show that mouse allograft inflammatory factor 1 (Aif1) is expressed by M cells and contributes to M-cell transcytosis. FAE in Aif1-/- mice has suppressed uptake of particles and commensal bacteria, compared with wild-type mice. Translocation of Yersinia enterocolitica, but not of Salmonella enterica serovar Typhimurium, leading to the generation of antigen-specific IgA antibodies, is also diminished in Aif1-deficient mice. Although beta1 integrin, which acts as a receptor for Y. enterocolitica via invasin protein, is expressed on the apical surface membranes of M cells, its active form is rarely found in Aif1-/- mice. These findings show that Aif1 is important for bacterial and particle transcytosis in M cells. |
