| First Author | Muranski P | Year | 2011 |
| Journal | Immunity | Volume | 35 |
| Issue | 6 | Pages | 972-85 |
| PubMed ID | 22177921 | Mgi Jnum | J:179285 |
| Mgi Id | MGI:5301744 | Doi | 10.1016/j.immuni.2011.09.019 |
| Citation | Muranski P, et al. (2011) Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature. Immunity 35(6):972-85 |
| abstractText | Th17 cells have been described as short lived, but this view is at odds with their capacity to trigger protracted damage to normal and transformed tissues. We report that Th17 cells, despite displaying low expression of CD27 and other phenotypic markers of terminal differentiation, efficiently eradicated tumors and caused autoimmunity, were long lived, and maintained a core molecular signature resembling early memory CD8(+) cells with stem cell-like properties. In addition, we found that Th17 cells had high expression of Tcf7, a direct target of the Wnt and beta-catenin signaling axis, and accumulated beta-catenin, a feature observed in stem cells. In vivo, Th17 cells gave rise to Th1-like effector cell progeny and also self-renewed and persisted as IL-17A-secreting cells. Multipotency was required for Th17 cell-mediated tumor eradication because effector cells deficient in IFN-gamma or IL-17A had impaired activity. Thus, Th17 cells are not always short lived and are a less-differentiated subset capable of superior persistence and functionality. |
