| First Author | Gon S | Year | 2018 |
| Journal | Haematologica | Volume | 103 |
| Issue | 6 | Pages | 999-1007 |
| PubMed ID | 29567770 | Mgi Jnum | J:317889 |
| Mgi Id | MGI:6859831 | Doi | 10.3324/haematol.2018.188359 |
| Citation | Gon S, et al. (2018) Fit alphabeta T-cell receptor suppresses leukemogenesis of Pten-deficient thymocytes. Haematologica 103(6):999-1007 |
| abstractText | Signaling through the alphabetaT cell receptor (TCR) is a crucial determinant of T-cell fate and can induce two opposite outcomes during thymocyte development: cell death or survival and differentiation. To date, the role played by T-cell receptor in the oncogenic transformation of developing T cells remains unclear. Here we show that human primary T-cell acute lymphoblastic leukemias expressing an alphabetaT cell receptor are frequently deficient for phosphatase and tensin homolog protein (PTEN), and fail to respond strongly to T-cell receptor activation. Using Pten-deficient T-cell acute lymphoblastic leukemia mouse models, we confirm that T-cell receptor signaling is involved in leukemogenesis. We show that abrogation of T-cell receptor expression accelerated tumor onset, while enforced expression of a fit transgenic T-cell receptor led to the development of T-cell receptor-negative lymphoma and delayed tumorigenesis. We further demonstrate that pre-tumoral Pten-deficient thymocytes harboring fit T-cell receptors undergo early clonal deletion, thus preventing their malignant transformation, while cells with unfit T-cell receptors that should normally be deleted during positive selection, pass selection and develop T-cell acute lymphoblastic leukemias. Altogether, our data show that fit T-cell receptor signaling suppresses tumor development mediated by Pten loss-of-function and point towards a role of Pten in positive selection. |
