| First Author | Hirai T | Year | 2021 |
| Journal | Immunity | Volume | 54 |
| Issue | 1 | Pages | 84-98.e5 |
| PubMed ID | 33212014 | Mgi Jnum | J:305822 |
| Mgi Id | MGI:6706545 | Doi | 10.1016/j.immuni.2020.10.022 |
| Citation | Hirai T, et al. (2021) Competition for Active TGFbeta Cytokine Allows for Selective Retention of Antigen-Specific Tissue- Resident Memory T Cells in the Epidermal Niche. Immunity 54(1):84-98.e5 |
| abstractText | Following antigen-driven expansion in lymph node, transforming growth factor-beta (TGFbeta) is required for differentiation of skin-recruited CD8(+) T cell effectors into epidermal resident memory T (Trm) cells and their epidermal persistence. We found that the source of TGFbeta -supporting Trm cells was autocrine. In addition, antigen-specific Trm cells that encountered cognate antigen in the skin, and bystander Trm cells that did not, both displayed long-term persistence in the epidermis under steady-state conditions. However, when the active-TGFbeta was limited or when new T cell clones were recruited into the epidermis, antigen-specific Trm cells were more efficiently retained than bystander Trm cells. Genetically enforced TGFbetaR signaling allowed bystander Trm cells to persist in the epidermis as efficiently as antigen-specific Trm cells in both contexts. Thus, competition between T cells for active TGFbeta represents an unappreciated selective pressure that promotes the accumulation and persistence of antigen-specific Trm cells in the epidermal niche. |
