| First Author | Cohen GS | Year | 2023 |
| Journal | Cell Rep | Volume | 42 |
| Issue | 8 | Pages | 112993 |
| PubMed ID | 37590141 | Mgi Jnum | J:339618 |
| Mgi Id | MGI:7523842 | Doi | 10.1016/j.celrep.2023.112993 |
| Citation | Cohen GS, et al. (2023) Transplantation elicits a clonally diverse CD8(+) T cell response that is comprised of potent CD43(+) effectors. Cell Rep 42(8):112993 |
| abstractText | CD8(+) T cells mediate acute rejection of allografts, which threatens the long-term survival of transplanted organs. Using MHC class I tetramers, we find that allogeneic CD8(+) T cells are present at an elevated naive precursor frequency relative to other epitopes, only modestly increase in number after grafting, and maintain high T cell receptor diversity throughout the immune response. While antigen-specific effector CD8(+) T cells poorly express the canonical effector marker KLRG-1, expression of the activated glycoform of CD43 defines potent effectors after transplantation. Activated CD43(+) effector T cells maintain high expression of the coreceptor induced T cell costimulator (ICOS) in the presence of CTLA-4 immunoglobulin (Ig), and dual CTLA-4 Ig/anti-ICOS treatment prolongs graft survival. These data demonstrate that graft-specific CD8(+) T cells have a distinct response profile relative to anti-pathogen CD8(+) T cells and that CD43 and ICOS are critical surface receptors that define potent effector CD8(+) T cell populations that form after transplantation. |
