| First Author | Nurieva RI | Year | 2009 |
| Journal | Science | Volume | 325 |
| Issue | 5943 | Pages | 1001-5 |
| PubMed ID | 19628815 | Mgi Jnum | J:151785 |
| Mgi Id | MGI:4355272 | Doi | 10.1126/science.1176676 |
| Citation | Nurieva RI, et al. (2009) Bcl6 mediates the development of T follicular helper cells. Science 325(5943):1001-5 |
| abstractText | A fundamental function of CD4+ helper T (T(H)) cells is the regulation of B cell-mediated humoral immunity. Development of T follicular helper (T(FH)) cells that provide help to B cells is mediated by the cytokines interleukin-6 and interleukin-21 but is independent of TH1, TH2, and TH17 effector cell lineages. Here, we characterize the function of Bcl6, a transcription factor selectively expressed in T(FH) cells. Bcl6 expression is regulated by interleukin-6 and interleukin-21. Bcl6 overexpression induced T(FH)-related gene expression and inhibited other T(H) lineage cell differentiation in a DNA binding-dependent manner. Moreover, Bcl6 deficiency in T cells resulted in impaired T(FH) cell development and germinal center reactions, and altered production of other effector T cell subsets. Our data thus illustrate that Bcl6 is required for programming of T(FH) cell generation. |
