| First Author | Napier RJ | Year | 2020 |
| Journal | Nat Commun | Volume | 11 |
| Issue | 1 | Pages | 5406 |
| PubMed ID | 33106495 | Mgi Jnum | J:298100 |
| Mgi Id | MGI:6470382 | Doi | 10.1038/s41467-020-18961-0 |
| Citation | Napier RJ, et al. (2020) T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis. Nat Commun 11(1):5406 |
| abstractText | Mutations in nucleotide-binding oligomerization domain-containing protein 2 (NOD2) cause Blau syndrome, an inflammatory disorder characterized by uveitis. The antimicrobial functions of Nod2 are well-established, yet the cellular mechanisms by which dysregulated Nod2 causes uveitis remain unknown. Here, we report a non-conventional, T cell-intrinsic function for Nod2 in suppression of Th17 immunity and experimental uveitis. Reconstitution of lymphopenic hosts with Nod2(-/-) CD4(+) T cells or retina-specific autoreactive CD4(+) T cells lacking Nod2 reveals a T cell-autonomous, Rip2-independent mechanism for Nod2 in uveitis. In naive animals, Nod2 operates downstream of TCR ligation to suppress activation of memory CD4(+) T cells that associate with an autoreactive-like profile involving IL-17 and Ccr7. Interestingly, CD4(+) T cells from two Blau syndrome patients show elevated IL-17 and increased CCR7. Our data define Nod2 as a T cell-intrinsic rheostat of Th17 immunity, and open new avenues for T cell-based therapies for Nod2-associated disorders such as Blau syndrome. |
