| First Author | Martinelli M | Year | 2023 |
| Journal | iScience | Volume | 26 |
| Issue | 1 | Pages | 105860 |
| PubMed ID | 36632062 | Mgi Jnum | J:332496 |
| Mgi Id | MGI:7427139 | Doi | 10.1016/j.isci.2022.105860 |
| Citation | Martinelli M, et al. (2023) The poly(C)-binding protein Pcbp2 is essential for CD4(+) T cell activation and proliferation. iScience 26(1):105860 |
| abstractText | The RNA-binding protein Pcbp2 is widely expressed in the innate and adaptive immune systems and is essential for mouse development. To determine whether Pcbp2 is required for CD4(+) T cell development and function, we derived mice with conditional Pcbp2 deletion in CD4(+) T cells and assessed their overall phenotype and proliferative responses to activating stimuli. We found that Pcbp2 is essential for T conventional cell (Tconv) proliferation, working through regulation of co-stimulatory signaling. Pcbp2 deficiency in the CD4(+) lineage did not impact Treg abundance in vivo or function in vitro. In addition, our data demonstrate a clear association between Pcbp2 control of Runx1 exon 6 splicing in CD4(+) T cells and a specific role for Pcbp2 in the maintenance of peripheral CD4(+) lymphocyte population size. Last, we show that Pcbp2 function is required for optimal in vivo Tconv cell activation in a T cell adoptive transfer colitis model system. |
